Bioactive alginates (low guluronate) to be produced in-vivo in bacteria, and by in-vitro epimerisation of high mannuronate alginates from seaweed or bacteria. They will be used for wound healing, health supportive fish feed, fish vaccines and also combined with biopolymers for enhanced performance.
In order to find new efficient and safe agents for gene delivery, the goal is to develop and produce already synthesized and designed novel charged amphiphiles on the basis of pyridinium derivates.
To develop, manufacture, test and introduce to the market a completely new type of medical device for vacuum therapy.
To select efficient symbiotic soil fungi for production of blueberries,raspberries&mulberries in arid ecosystems.The outcome will be novel mycorrhizal inocula tuned to increase stress tolerance of plants&reduce the input of agrochemicals.
The construction of new hybridoma cell lines producing monoclonal antibodies, construction of fluorochrome labelled antibodies for diagnostic purposes, and certification of selected reagents as in-vitro diagnostics.
An innovative technology for robust high-productivity processes will be established and scaled-up. A compendium of the knowledge gathered regarding mixed substrate cultivation will be made available.
Development of different dosage forms containing doxycycline alone or associated with paracetamol or others, for improving the extrinsic and intrinsic characteristics for a safe and rationale use of this antibiotic in animal health.
Prototype hiv vaccines consisting of dna vectors that express either single hiv genes or artificial genes consisting of several genes and gene fragments will be tested for safety, immunogenicity and therapeutic effect in clinical trials and for a therapeutic effect in an animal model.
Signalling proteins will be prepared using recombinant techniques and used for making poly and monoclonal antibodies. Antibodies to cell surface receptors will be labelled using modern fluorochromes. These products will be marketed by the czech biotech company exbio.
To develop algorithms for evaluating the region of intracranial saccular aneurysms on angiography images, and to implement the new method in computer aided medical diagnostic tools for use with personal computers.