EUREKA PROJECT > 4984 VEGEPHY
- SUMMARY
- OUTLINE
- PARTICIPANTS
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BELGIUM
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FRANCE
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FRANCE
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BELGIUM
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BELGIUM
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BELGIUM
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FRANCEFormulation on vegetable oil base for phytosanitory protection and its application protocol
Development of an oil for the treatment of seed potatoes to fight against transmission by the aphid of the virus Y and of an adjuvant for a phytosanitory product with improved adherence properties thanks to the addition of polysaccharides which give these treatments better targeting.
Status > ANNOUNCED - 28-Jun-2009 Technological Area Market Area Start Date > 30-Jun-2009 Duration > 36 Months Participating countries > FRANCE, BELGIUM | Main contactComptoir Commercial des Lubrifiants (CCL) Mr. Philippe Paillisson > General Manager Organisation type > SME |
Project Description
The phyto-pharmaceutical compounds and the oils are used to fight diseases in many crops to eradicate insects that are responsible of the transmission of virus diseases that are detrimental to the development and quality of the harvests of the crops. Now insecticides and mineral oils are sprayed in high to very high doses on crops to avoid the development of these diseases. The project consists in understanding (i) the mechanisms of action of the oils and their capacity to inhibit this vector of virus and (ii) the reaction of the plants towards these insects and these oils in order to make a better formulation. The vegetable basis (oils and esters) more compatible with the evolution of the fossil resources market and the pressures for human and environment protection - elimination of mineral oils and pesticides - are the chosen orientations after the first trials and are the investigation lines for the preparation of a formulation. This first step aims to elaborate an efficient composition for this treatment that can answer to the market demands. The second step consists in studying the quality of the spraying in order to maximise the transfer of the active ingredient into the plant. The quality of application is studied through the rheology and the properties of the superficial tensions of the oil emulsions during the spraying (size of the particles) in order to identify the factors that influence the drift; it means limiting the thin particles lost in the atmosphere and the heaviest particles that fall down the soil. Indeed the reduction of these 2 factors maximises the quantity of active product in the plant and consequently it brings better global efficiency. Moreover, the interfacial properties are studied with the phenomenon of wetting, adherence or rebound of the particles and penetration of the substrates, in order to create the best conditions for the reaction of the active ingredient that has reached its objective and to ensure maximum efficiency of the treatment. This study is completed by the study of the residues of the active ingredient in the plant that could be the consequence of the use of adjuvants that are maximisers of efficiency. The maximum residues level (MRL) established by the law imposes us to verify at each level of treatment the factors that influence the evolution of the concentrations of the active ingredients that can remain in the final product, integrating at the same time more efficiency of the active ingredient, a better transfer, more adherence and penetration that brings a better efficiency of the treatment and also consequently a reduction of the quantities of the active ingredients used. Validation in the field with biological trials at each step of selection will allow for finding the compounds of the formulation. All these factors are major for the formulation of an oil to protect the plant against the virus diseases and also for its mean of transfer to reach the crop to treat. Study in real conditions of the new technical itineraries in order to optimise the treatment in their concentration and dose to apply.
Technological Development Envisaged
According to Rohrbach (1988), mineral oils have been used since 1930 in order to reduce the cochineal insect populations with a slight decrease of the virus transmission in pineapple plants. Today these mineral oils are used in the seed potato culture and also in lower quantities in fruit trees. Their commercial development is however limited due to the very high efficiency of the insecticides of synthesis. The vegetable oils have toxic properties against acaroids and make an opposition to the inoculation of non-persistent virus by the aphid on pear trees - reduction of 40% of the virus - (Martin et al. 2006) and on seed potatoes, but are often associated with insecticides. P. Giordanengo showed the absence of insecticide action of the oils on the aphids (Ameline et al. 2006, Martoub et al. 2008). The action of the mineral or vegetable oils that lead to the reduction of the virus diseases is still unknown; recent studies show a preventive effect and the induction of an early defence answer of the plant. The intervention of lipids in the defence mechanisms (Molina et al 1993; Guerdoni et al 2002) suggests an elicitor role that is at the origin of the systemic answer of the plant.
Main contactRedebel Mr. Tanguy Dumont de Chassart > General Manager Organisation type > Other |
Contribution to project
The organisation will contribute to advice for the choice of the co-formulants that will be used in oils, taking into account the EU Regulation (inscription to annex I and related legislations) to avoid the use of co-formulants, which will lead to demonstrating the non-toxicity of the preparations for humans, animals as well as the environment. The important point is also to be in line with international and national regulations concerning the placing on the market of preparations intended to be used. REDEBEL is initially checking and closely following EU legislation in order to finalise a perfectly compatible product with the market evolution. In fact, products have to comply with 91/414 (and its revised version) as well as with the REACH regulation on basic substances that will enter into the composition of the product. There will be mplementation in "real-time" of tests on the materials used to produce at the end of the study to have the assurance of formulations that meet the specifications for registration.
Expertise
REDEBEL is a consultancy company (CRO) active in the following domains: Pesticides, Biocides and Reach regulations. Its activities are mainly the registration of Plant Protection Products, Biocides and Molecules falling within Reach but also field trials for plant protection products. 1. Registration - Advice on different legislation; - Building of Registration Core Dossier for EU and national Levels; - Follow-up at EU and national Level; - Management of integrated projects (from the molecule to the registration). 2. Field trials - GEP (efficacy and selectivity of Plant Protection Products on all cultures); - GLP (residue trials on all cultures).
Main contactComite Nord Mr. Yves Begue > Directeur Organisation type > Other |
Contribution to project
- Technology of the seed potato culture. - Biological trials in the laboratory, greenhouse and the field on the seed potatoes all along the evolution of the study. - Validation of the choices elaborated in common with CCL and UPJV in the active ingredients (oils, oil esters, oil polymers). - Trials on the adjuvants in relation with the active oils. - Bringing to the fore the contribution of the adjuvants on the activity of the oils and of the applied treatment products on the seed potatoes. - Analyses of these seed potatoes (virology). - Effects of the oils and of the adjuvants on the evolution of the residues in relation with CRA gx. - Study of the technical itineraries in the application of the oils in the treatment of the virus diseases and in the phytosanitory treatments, looking at the mixtures according to the revealed activities. - Take into account the number of passages, the concentration and litres/ha of active ingredients in relation with the yield in virus-free seed, and more generally with the obtained quality. - Minimise the costs of the inputs. - Conclusion and validation of the new methods and advised preparations.
Expertise
The FNPPPT (NATIONAL FEDERATION OF FRENCH SEED POTATO GROWERS) and its regional growers establishments (Comite Nord represents 65% of FNPPPT) has been recognised as a technical Institute. * Technical and phytosanitory work following seed potato production for the different markets (fresh market, human industry, starch industry). * Laboratory for in-vitro multiplication. * Greenhouses for production without soil. * Station for experimentation recognised for Good Practice of Experimentation. * Laboratory of phytosanitory testing (virus, bacteria, nematodes, fungi) certified COFRAC in virology and bacteriology. * Tests for variety identification.
Main contactUTC - Universite Technologique de Compiegne / Integrated Transformations of Renewable Matter) Prof. Daniele Clausse > Organisation type > University |
Contribution to project
Fundamental research about: - Formulation, emulsification and characterisation of complex products having shown positive activity. New formulations are proposed in the project. Main techniques: microscopy, rheology, calorimetry. - Spraying: interfacial properties liquid/air, control of the composition of the droplets. Main techniques: tensiometry, calorimetry, high speed video monitoring. - Interfacial properties between the leaves and the formulation: rebound, adherence and flow on model surfaces and on real surfaces. Main techniques: tensiometry and high speed video monitoring - Transfer technology between laboratory researches and industrial applications: scale-up of the emulsification process.
Expertise
- Formulation, fabrication and characterisation of dispersed systems: emulsions, foams, suspensions and powders. - Use properties: encapsulation, release, spraying, foaming, wettability, adsorption. - Process engineering and in particular agricultural engineering.
Main contactFYSAGx / UMC-BEAGx-LP Prof. Frederic Lebeau > Charge de Recherche Organisation type > University |
Contribution to project
Optimisation of the pesticide transfer and behaviour on the plant (Task 3) through three aspects: - Spray drift measurement in controlled conditions for the formulations developed. Measurements are carried out in the UMC's wind tunnel with BEAGx and LP. - Measuring the effect of formulation on the droplet sizes of the spray nozzles. The droplet sizes of the spray pattern is analysed by PTVS (Particle Tracking Velocimetry Sizing) for different formulations in order to compare their effect on this parameter in terms of transfer. - Measuring the impact of formulation on the adhesion properties and rebound of droplets. A piezoelectric generator, a fast scan camera and a fast pulsed light are used to visualise the impact of droplets with defined properties on different kinds of substrates.
Expertise
Presentation of "UNITE DE MECANIQUE ET CONSTRUCTION (UMC)" "L'UNITE DE MECANIQUE ET CONSTRUCTION" has been active for many years in research concerning pesticide application methods. The main topics of research in this area are the quality of the distribution, drift and dispersion modelling of pollutants, the dynamic behaviour of spray booms, the measurement of the kinematics of particle imaging using PIV (Particle Image Velocimetry) and PTVS as well as at the development of environmental indicators. Among the equipment available, the laboratory provides many measurement facilities and environmental engineering sensors. Among these facilities, a pesticide drift wind tunnel and many types of imaging devices are relevant to the study. Presentation of "BEAGx-CA-LP" The research group "BEAGx (Bureau d'etude Environnement et Analyses) CA (Chimie Analytique) -LP (laboratoire de phytophamacie)" is specialised in the study of pollutant residues in the environment. As such, it has a Good Laboratory Practice certificate (GLP GLP-F01) and provides services in research and analysis for homologation of plant protection products and biocides.
Main contactUniversite de Picardie Jules Verne (UPJV) Dr. Philippe Giordanengo > Maitre de Conferences Organisation type > University |
Contribution to project
* Searching for oils and oil derivatives inhibiting non-persistent virus transmission by sap-sucking insects. * Biological activity: direct effects on insect vectors (antibiosis or antixenosis); indirect effects through plant response (early and late response). * Selection of formulation components.
Expertise
* Eco-physiology of plant/insect interaction. * Non-persistent virus transmission by sap-sucking insects. * Plant resistance to pests. * Genomic, molecular and metabolic plant responses to biotic stresses (insects and pathogens). * Plant hypersensitive response. * Bio-pesticides and elicitors of plant defence. * Lipid biochemistry and metabolism and plant secondary metabolism. * Biotechnology, biochemistry, analytical chemistry, biology.
Main contactCRA-W / Pesticides Research Department, Chemistry Section Mr. Gilles Rousseau > Attache Scientifique Organisation type > Research Institute |
Contribution to project
Influence of the use of the extemporaneous adjuvant (external to the formulation) on pesticide residue levels (subtask 2.2) - Bibliographic study. - Selection of target crops according to their sensitivity to accumulation of residues and their interest. - Selection of relevant pesticides. Selection of products based on their biological function (herbicides, fungicides, insecticides and plant growth regulators), the type of formulation, and their method of application. - Conducting of trials in fields or greenhouses with treatments associated or not with the extemporaneous adjuvant. - Development of analytical methods based on the residues of plant protection products studied and the different matrices tested. - Validation of analytical methods developed. - Analysis of residues on the samples generated in the testing fields. - Evaluation of the influence of the extemporaneous adjuvant on residue levels and integration of these results to European legal frameworks (MRLs). These results will also be used in addition to efficacy trials and optimisation trials of the treatment using the adjuvant. Study into approval of the formulations obtained (subtask 5.3: Constitution of the chemical dossier): - Studies on physico-chemical properties of adjuvant formulations in accordance with European regulations and FAO (Food and Agricultural Organisation) specifications (as Good Laboratory Practices). - Studies of pesticide residues of plant protection products used in combination with the adjuvant according to European legislation and in accordance with GLP and including: * Testing of pesticide residues in accordance with the requirements established by REDEBEL in order to define precisely the use(s) or product(s) for which approval is sought (the number of applications, timing of applications, time interval between last application and harvest (DAA), etc.). * Development of analytical methods suitable for plant protection products and matrices referred for approval. * Validation of analytical methods developed according to GLP. * Analysis of pesticide residues in samples taken from the plots.
Expertise
WALLOON AGRICULTURAL RESEARCH CENTRE OF GEMBLOUX (CRA-W) - Pesticides Research Department, Chemistry Section. The Pesticides Research Department of CRA-W combines the skills of chemists and agronomists to develop reliable crop protection tools, meeting the expectations of society: environmental compliance and public health. Knowledge of plant protection products (PP) remains the basis of its activities, and covers the following areas: - Chemical and physico-chemical properties of PP and biocides and establishing specifications; - Characterisation and quality of treatment (seeds, nets, etc.); - Efficiency and selectivity of PP; resistance to PP; - Fate of PP in agricultural crops and water (residues); - Regulations on the PP and practical implications (good agricultural practices). The services provided by the Department meet internationally recognized standards (GLP, GEP, ISO 17025). The chemistry section studies the chemical and physico-chemical properties of plant protection products, and their fates in crops and the environment. The section researches, develops and validates analytical methods for active ingredients, impurities, their formulations, and residues of pesticides and their metabolites resulting from their use. To accomplish these tasks, the laboratory is equipped with all modern techniques of analysis of pesticides such as gas chromatography (GC-MS, GC-FID, GC-ECD, GC-NPD) and high-performance liquid chromatography (UPLC-MS/MS, LC-MS/MS, HPLC-DAD, HPLC-Fluo).
Main contactComptoir Commercial des Lubrifiants (CCL) Mr. Philippe Paillisson > General Manager Organisation type > SME |
Contribution to project
- Formulation of adjuvants and oils considered as insecticides. - Transfer of technology from UTC (UNIVERSITE DE TECHNOLOGIE DE COMPIEGNE) to CCL. - Biological trials in fields with adjuvants. - Validation of the properties of the active oil on seed potato. - Validation of the properties of the adjuvants. - Management of the project through subcontractors. - Approach of the extension of the project to other crops. - Development of collaboration with INRA, technical centres, schools and agricultural organisations to consolidate the project. - Application of the properties of the adjuvant for the reduction of the dose of pesticides.
Expertise
CCL makes the formula, and makes and spreads the helpers for the phytosanitory treatments. * Oils for treating crops against acaroids, cochineal insects and aphids (authorised on biological crops). * Adjuvants for all phytosanitory treatments: herbicides, fungicides, insecticides and growing regulators on field crops, fruit trees, citrus trees, vineyard, and green areas. * Biological trials in fields following the protocols of Good Practices of Experimentation for a final validation in internal trials and in a network of specific technical centres. * Knowledge of the market in its technical objectives.
Main contactVandeputte Oleochemicals Mr. Pierre-Marie Baudoin > Directeur usien & recherche Organisation type > Large company |
Contribution to project
Through VEGEPHY, VANDEPUTTE OLEOCHEMICALS will be in charge of orientating the partners in the choice of oils and derivatives that will enter in the composition of the product. VANDEPUTTE OLEOCHEMICALS offers a wide range of vegetable oils and their derivatives, with very good knowledge. The company at any time is able to answer to the technical needs of the study, by developing new products, and supply vegetable oils with profiles identified. The company is also specialised in the analytical characterisation of the oils.
Expertise
Today, VANDEPUTTE is constituted by a holding which is composed of 3 corporations whose business is primarily oriented around a common thread: flaxseed. The youngest company of the group, VANDEPUTTE OLEOCHEMICALS, specialised in the production of oils derived from flax (oil technology) is a company that was founded in 2001. It has 20 employees and annual revenues of EUR 7.7 million (2007). The company produces over 8,000 tons of vegetable oil derivatives, mainly based on linseed oil as well as soybean, castor, rapeseed, safflower, etc. for traditional applications such as coatings, inks, paints, resins, pre-polymers, but also in innovative applications such lubricants, various additives, etc. VANDEPUTTE OLEOCHEMICALS has a structure of R&D specialised in the development of technical products from vegetable oils. Active in the field of polymers for 10 years, VANDEPUTTE OLEOCHEMICALS has competence in development of additivation polyesters, polyurethanes and PVC. VANDEPUTTE has participated in several national and European research projects: Walloon project OLEOPLAST (plasticizers - new products from vegetable oils), European project STANLUB (new lubricants and solvents for paints from vegetable oils), European project IBIOLAB (improving the development and production of biolubricants by obtaining Ecolabels in a wide range of applications). VANDEPUTTE OLEOCHEMICALS also has a patent (EP1172395: Process for preparing polymerizable coating or moulding compositions) jointly filed with the company TREVE.
Main contactMosselman Mr. Luc Dassonville > Administrateur Delegue Organisation type > SME |
Contribution to project
Contribution to choosing the right tension active and fatty acid ester which meets the need of the project at different stages of the formulation and application. This contribution consists of the study of the interfacial tensions water/oil to form the emulsions of oil or vegetable fatty acid ester and also the interfacial emulsions water/air during the pulverisation and granulometric distribution resulting therefrom, and also the interfacial emulsions water/leaves of the plants to treat to assure a maximum humidification of the substrate without limiting the adherence. The choice of the right tension active has to take into account the toxic character, the eco-toxicity and the environmental behaviour through biodegradability and through the behaviour in the soil. These same criteria are also applicable for the choice of the right fatty acid ester serving as a base for the additives and the 'treating oils'.
Expertise
MOSSELMAN is specialised in the production of oleo-chemical products. The product range consists of vegetable oils, animal oils, fatty acids, fatty alcohols, fatty acid esters, glycerine, alcanolamides, metal stearates, natural and synthetic waxes, non-ionic surfactants, anionic surfactants and cationic surfactants. The range of tension active products is very broad and consists of products of vegetable origin (e.g. lectihins), products made out of renewable sources (e.g. sorbitan mono oleate, glycerol mono oleates) and products produced out of mainly vegetable sources (fatty alcohol ethoxylates). The vegetable fatty acid ester product range incorporates all the fatty acids from C8 to C24 and can be mono, di or based on different polyols. There is expertise for emulsifying and developing wetting agents, and also determining the importance of the fatty acid chain distribution of the fatty acid esters.