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Simulating measurement uncertainty in chemical measurements

Development of a software system for low-cost, high quality uncertainty calculations in chemical measurements in order to promote the mutual recognition of test results and make international trade easier, especially in in the pharmaceutical and food sectors.

Diverse international organizations (WTO (World Tourism Organisation), ISO (International Standards Organisation), BIPM, ILAC, etc.) have developed many concepts to promote the mutual recognition of test results and make international trade easier. These concepts show that mutual recognition of test results is only within reach if the measurement uncertainty of the results is known. Considering that determining the overall measurement uncertainty according to ISO implies great efforts, the demand for suitable software systems within all the sectors of metrology will increase. Up to now, software systems have to meet high quality standards, especially in the pharmaceutical and food sectors. They must conform to the requirements of FDA Guideline 21 CFR Part 11 (cf. www.21cfrpart11.com, FDA (Food and Drug Administration of the U.S.A.)). Within the range of the preceding EUREKA Project E! 1910, the first part of a software system for quantifying uncertainty in analytical measurements has been developed. It consists of the uncertainty calculator kernel and of the chemical modules Titration, ICP-OES (Intrinsically Conductive Polymer-Optical Emission Spectroscopy), HPLC (High Performance Liquid Chromatography) and inorganic sample preparation. The present project intends to develop the modules GC (Gas Chromatography), GC-MS (Gas Chromatography-Mass Spectrometer), LC-MS (Liquid Chromatography-Mass Spectrometer, IC (Ion Chromatography), ICP-MS (intrinsically Conductive Polymer-Mass Spectrometer), voltammetry, organic sample preparation and sampling. These techniques are mainly based on physical and chemical principles other than the methods taken into account in the first project. That is why totally new models need to be developed for measurement uncertainty. The project team includes both research institutes in analytical chemistry and routine laboratories, taking into account their needs as representatives of the future users. A specialised software company is being charged by EMPA to carry out the codification.
Acronym: 
UNCERTAINTYMANAGER
Project ID: 
3 106
Start date: 
01-06-2003
Project Duration: 
24months
Project costs: 
1 000 000.00€
Technological Area: 
Analyses / Test Facilities and Methods
Market Area: 

Raising the productivity and competitiveness of European businesses through technology. Boosting national economies on the international market, and strengthening the basis for sustainable prosperity and employment.