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Bioresorbable textile materials from biodegradable polyester blends

Surgical textile materials for external and internal wound closure will be developed based on blends of biodegradable and biocompatible polyesters including synthetic analogues of biopolymers.

It is commonly known that surgical interventions on internal organs are accompanied by problems of wound closure. Different factors can be referred to as causative, i.e. tension in the tissues, bleeding-and-suturing vicious circle (management of organ bleeding through suturing whereas needle puncture causes another bleeding point), lack of suturable tissue, etc. A commonly used method for managing internal wounds is electro-coagulation of the blood vessels to obtain haemostasis. Such a method, in most cases, leads to postoperative adhesion formation that may affect both postoperative run up and improve patient's life quality. An alternative surgical method is suturing. Unluckily, every suture, especially on peritoneum, mechanically harms this serous membrane and evokes its physiological response. A major clinical problem relating to postoperative surgical repair - or inflammatory disease - is the adhesion of organs, which occurs during the initial phase of the healing process after surgery. "Adhesion" is a pathological condition, where the formation of abnormal tissue linkages occurs. These linkages can impair bodily function, result in infertility, and obstruct the intestines (bowel obstruction) or produce general discomfort, e.g. pelvic pain. Various attempts have been made to prevent postoperative adhesions (modification of surgical methods into minimally invasive, laparoscopic surgical techniques, use of physical barriers - films, gels and various solutions for wound or cavity lavage). Unfortunately, very limited success has been seen with these methods. A very promising method for eliminating or reducing post-surgical tissue adhesion seems to be the use of bioresorbable polymer materials. Biodegradable and biocompatible polyesters have attracted much attention by polymer and material scientists owing to their potential capability for being applied as wound dressing, surgical implants and other medical devices. Depending on the application foreseen, the physical properties of the biomaterial should be tuned to match the specific application requirements. Knowledge of structure-property relations in biodegradable polyesters and biomaterials derived from there, is crucial to succeed in 'ad hoc' modification of physical, mechanical and thermal properties. The present project is based on previously acquired expertise on structure-property relations in biodegradable polyesters, co-polyesters and their blends. Particularly relevant to this project is a method of forming surgical yarn materials for postoperative wound protection, from biodegradable binary blends of atactic poly(3-hydroxybutyrate) with poly-(L) - lactide and lactide copolymers respectively. Medical textiles are to be obtained from biomaterials using spinning from solutions or from melting, conventional textile methods (weaving, knitting) and non-conventional methods as well as elaborated specific finishing methods in accordance with the clinical use of the products. The fibres and yarns produced from the blends prepared will be based on the results of the rheological study of the spinning solution. Another aim of this project is the processing of yarns in clinical application products, by suitable correlation of technological parameters specific to mechano-textile processes (conventional technologies), in order to provide the required performance level of functional parameters: patterns, controlled thickness, threads/cm, porosity, permeability etc. The obtained fibres will be used for producing dressing materials through non-conventional technologies. Studies regarding the structure of the polymeric materials before and after the sterilisation with different agents (steam, ethylene oxide, gamma Co 60 irradiation) will also be carried out. The project will be structured in the following steps: 1. The optimisation of conditions and scaling-up of the synthesis of blend components i.e.: poly (L) - lactide, poly (L-lactide-co-glycolide) and atactic poly (3-hydroxybutyrate). 2. Preparation of blends and optimisation of blend compositions and blending methods. 3. Experimental production of monofilaments, filaments and braided yarns with blends. The working up of fibber pulling and establishment of specific parameters. 4. Transforming the fibber into clinically applicable forms through conventional and non-conventional mechanical textile technologies (knitting, weaving, non-weaving or braided). 5. Testing and optimisation of sterilisation methods of obtained materials. 6. Performing 'in-vitro' and 'in-vivo' tests in order to evaluate the biomedical and biofunctional levels of performance in accordance with the norms in force in the EUROPEAN COMMUNITY. Keywords: biomaterials, polyesters, surgical textile.
Acronym: 
BIOTEXTIL
Project ID: 
3 420
Start date: 
01-07-2005
Project Duration: 
36months
Project costs: 
1 200 000.00€
Technological Area: 
Textiles Technology
Market Area: 
Disposable products

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