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The development of the multifunctional semisolid preparations from natural products

Environmentally friendly semi solid preparation from natural ecological sources will be created. This qualitatively new cream will retard cell aging, strengthen the antimicrobial barrier of the skin and promote healthy healing.

The new cosmetic cream will be created from natural products. Traditionally drugs and cosmetics used by man were of natural origin. Nowadays preparations from natural raw materials are more and more often used for prophylaxis and the treatment of many diseases as well as for cosmetic purposes when compared to synthetic preparations. Natural preparations have wide pharmacological properties and are not habit-forming. They are better tolerated and their side effects are significantly weaker when compared to synthetic preparations. The site of the therapeutic activity of the developed cream is the skin surface, where the ingredients of the cream would strengthen the antimicrobial barrier of the skin, thus providing the protective function. Skin, as well as the mucosa of the urogenital, digestive and respiratory tracts, protect the internal body structure from the hostile external environment, i.e. the changing pollution, temperature, humidity and radiation. The skin protects internal organs, limits the transition of chemical substances to and from the body, stabilizes blood pressure and temperature, and renders the senses of heat, cold, touch, and pain. The barrier function of the skin can be manipulated. For instance, topical antibiotics and antibacterial substances help the damaged barrier to protect itself from infection and sunscreens, while the corneous layer protects live tissues from ultraviolet radiation. Softening preparations restore the elasticity of the corneous layer. This necessitates the selection of a suitable cream basis in order to achieve an optimal therapeutic effect in the target skin layer. Propolis is an apian product collected by honeybees from many plant sources. Due to pain and inflammation relief, and wound repair enhancing properties, propolis was used in folk medicine as early as 300 BC (Burdock 1998, Marcucci et al., 2001). Nowadays it is known that propolis has strong antibacterial and antifungal activity due to flavonoids, terpenoids, aromatic acid esters etc. (Kujumgiev et al., 1999, Lu et al., 2005). However the mechanisms of antibacterial action of propolis is not well known. Propolis has strong viricidal properties. It was shown that propolis inhibits herpes simplex type 1 and 2, adenovirus type 2, influenza viruses A and B, and human immunodeficiency virus type 1 (Burdock 1998, Gekker et al., 2005). It is well known that free radicals are important in cell aging. Free radicals react easily with cell structures, damaging proteins, lipids and DNA (Deoxyribose Nucleic Acid). There are many reports indicating that the ethanol extract of propolis has strong antioxidant properties due to the high content of flavonoids. It seems that flavonoids behave at the initiation stage of lipid peroxidation as scavengers which react with peroxy radicals of polyunsaturated fatty acids, breaking the chain reaction (Nagai et al., 2003; Middleton et al., 2000), thereby protecting lipids and other compounds from being oxidized or destroyed. Some recent publications have indicated the anti-tumour activity of propolis. Studies showed that prenylflavanones could effectively induce human melanoma cell apoptosis (Chen CN et al., 2004), aromatic acid ester (benzyl, phenethyl and cinnamyl caffeates) possessed anti-proliferative activity against murine B16-BL6 melanoma (Banskota et al., 2002). Propolis has been shown to stimulate various enzyme systems, cell metabolism and collagen formation as well as improve the healing of burn wounds (Krell 1996). These effects have been shown to be the result of the presence of arginine in propolis (Gabrys et al., 1986). In addition, propolis disinfects and promotes healthy healing - helps to heal cuts, scrapes, acne, burns, sunburns. Thus, taking together all research data, it appears that propolis due to its antioxidant, antimicrobial action and tissue regeneration as well as skin-healing properties could be a very suitable active compound for the development of cosmetic products from natural sources. All these properties of propolis could be widely used in cosmetology for creating new products. Keywords: natural products, cream, propolis.
Acronym: 
PROPOCREAM
Project ID: 
3 694
Start date: 
01-07-2006
Project Duration: 
38months
Project costs: 
380 000.00€
Technological Area: 
Virus, Virology, Vaccines/ Antiobiotics / Bacteriology
Market Area: 
Health and beauty aids

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