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Second harmonic generation imaging using a confocal microscope

Second harmonic generation (shg) can generate a wave with twice the optical frequency. Multiphoton microscopy, including shg, produces high-resolution, three-dimensional pictures of tissue with minimal damage to living cells.

The main goal of this project is to acquire knowledge on optics and second harmonic photon behaviour of bio-materials, so that current issues on research and real-time treatment of living bio-tissue can be resolved. This will result in the development of innovative Second-Harmonic Generation (SHG) Microscope technology for application in research, diagnostics, clinical treatment and drug (protocol) development. In this project, partners aim to generate the intellectual framework, generic knowledge, concepts and models to study Second-Harmonic-Generation Microscopy and develop an innovative system prototype. The project envisages a new practical approach on available basic research results from second harmonic generation microscopy, resulting in addressing current major issues in SHG microscopy: - Novel efficient optics, for combined visible and infrared photon sampling. - New photon shielding and filtering technology, for absolute selection of specimen photons. - New rapid photon detection, with high refresh rates for absolute real-time selection of specimen photons. Keywords: microscopy, lasers, cancer.
Acronym: 
SHGENIUS CONFMIC
Project ID: 
3 945
Start date: 
01-05-2006
Project Duration: 
54months
Project costs: 
1 510 000.00€
Technological Area: 
Optical Technology related to measurements
Market Area: 
Diagnostic test products and equipment

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