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Comprehensive processing of plant extracts for high value added products

Harvesting and the newest high pressure and deep vacuum techniques in production of standardized plant extracts/bioactive molecules for application in formulation of nutraceuticals/medicine. In vivo studies to support evidence for health benefits.

The aim of this project is processing of plant extracts for high added value products. Nowadays, plants and plant extracts as sources of valuable active substances are in the focus of scientific attention. One reason is appearance and spreading of multiresistant and panresistant agents around the world leading to severe infections in humans and animals. The World Health Organization has declared the spreading of panresistant bacterial strains "pandemic of panresistance" because these strains were found in all countries and on all continents. Still, there is not a one specific solution for this phenomenon. Infections caused by panresistant agents lead to death in more than 90% of the cases. This is why the scientists in the scientific literature call bacterial resistance to antibiotics "the plague of the 21st century". In this context, plants are considered as sources of non-antibiotic substances with antibacterial activity, at the same time with no contribution to further increase of the resistance. Another reason for utilization of plant extracts is their complex multi-component nature that may be especially well suitable for interfering simultaneously with multiple targets, encompassing the possibility of low-dose administration of active agents and therefore reducing the potential undesired events, while at the same time providing prospective synergistic or additive effects. According to the EU market reports and forecasts in 2014, herbal/traditional products are generally expected to grow in popularity over the forecast period of four years in line with the ongoing health and wellness trend which includes consumers’ growing wish to substitute potentially harmful chemicals with natural products. In the definition phase of the project, standardized extracts will be produced from plant material using the latest high pressure separation techniques applying supercritical fluids, deep vacuum separation techniques as well as conventional methods. The research will be performed with hop (Humulus lupulus L.), industrial hemp (Cannabis sativa L.), feverfew (Tanacetum parthenium), vine industry waste (grape seeds and pomace) and other medicinal plants. In the implementation phase of the project, technologies for the production of standardized/stabilized extracts will be elaborated, in vivo tests will be performed and added value products based on the obtained standardized extracts will be formulated. Partner from Germany is interested in development of a special harvesting system for industrial hemp, which allows harvesting the plant tops for extraction purposes and the straw for fiber applications. The system will expand the new agricultural profit- field of the raw material harvesting for hemp extracts. Polish partners are interested in production of standardized extracts from hop and Cannabis sativa and preclinical safety and efficacy studies to support evidence for health benefits for humans of the novel nutraceuticals/medicine with strong biological activities. Serbian partners are interested in formulation of a cream with antibacterial properties for treatment of skin infections including infections with resistant strains, decubital and diabetics wounds, as well as in production of stabilized extract of Tanacetum parthenium. Partners from Montenegro are interested in application of plant extracts in formulations for topical use and in utilization of vine industry waste for the isolation of natural active compounds for implementation in cosmetics and dermatics . The intellectual property obtained will be divided as property of research institutions and enterprises involved. Total planned costs of the project are 923 954 € (nine hundred twenty three thousand nine hundred fifty four EUR).
Acronym: 
COMPLANT
Project ID: 
9 906
Start date: 
01-01-2016
Project Duration: 
32months
Project costs: 
830 000.00€
Technological Area: 
Nutrition and Health
Market Area: 
MEDICAL / HEALTH RELATED

Raising the productivity and competitiveness of European businesses through technology. Boosting national economies on the international market, and strengthening the basis for sustainable prosperity and employment.