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Development and production of water-dispersible radionuclide labeled magnetic nanoparticles

Water-based series of magnetic nanoparticles coated/embedded into polymers and other organic materials will be designed and produced. They can be used as agent for mri and magnetic hyperthermia applications as well as functionalised with radionuclides for potential using in radionuclide therapy.

The main objective of the proposed project is focused on the research, development and production of magnetite nanoparticles (MNPs) for potential applications in cancer therapy, magnetic hyperthermia and radionuclide therapy. The majority of nanomaterial assignments are aimed towards cancer combat which has one of the highest priorities in the health strategy of many countries. Namely, malignant diseases are second to the cardio vascular diseases among the most frequent death causes. The situation in county of the project coordination (Serbia) is even more alarming since number of deceased due to malignant diseases is in the steep increase in the last decade: the 13% increase over 5 years period was recorded which is the highest rate in Europe. This fact emphasized the importance of mobilizing the widest possible range of experts for contributing to cancer combat. This project is aimed to interdisciplinary research for the development and production of new nanomaterial-based agents for cancer therapy and diagnostics. Within the proposed research we will use the state-of-the-art techniques in nanotechnology to design multifunctional MNPs. Having in mind therapy purpose it will be our goal to prepare modified magnetic nanoparticles that could be labelled with beta emitting radionuclides and attract the particles to a targeted site by external magnetic field until the therapy is complete. Since the Serbian group is the main objective of the proposed project is to magnetic nanoparticles followed by their radiolabeling by beta-emitting radionuclides 90Y. This offers several advantages to commercial available diagnostic and therapeutic agents. The as-prepared MNPs will be based on magnetite (FE3O4) due to its high biocompatibility, price and simple preparation. However, interactions among MNPs result in formation of agglomerates and form large clusters with very strong magnetic attractions what causes its colloidal instability. In order to obtain a stable non-aggregating water dispersion with desired magnetic characteristics, different biocompatible coating materials will be used. Synthesized magnetite base nanoparticles will be capable or functionalized with radionuclides and other drugs by development of novel binding procedures. The method will be irreversible to prevent radionuclide escape and, secondly, due to short half-life times of some radionuclides, the manufacturing process will be not time-consuming and too complex because of the risk of contamination. Biological characteristics of radioactive MNPs will be determined by their testing in-vitro and in-vivo. The process of preparation will be optimized in order to gain radioactive MNPs with promising physico-chemical properties for potential application in cancer therapy. In addition, some of MNPs will be also prepared and tested as potential contrast agents in magnetic resonance imaging and in magnetic hyperthermia.
Acronym: 
NANORADIOMAG
Project ID: 
9 982
Start date: 
01-01-2016
Project Duration: 
36months
Project costs: 
600 000.00€
Technological Area: 
CHEMISTRY, PHYSICAL AND EXACT SCIENCES
Market Area: 
Chemicals and Materials

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